Segmental and focal glomerulosclerosis. Case report
DOI:
https://doi.org/10.61997/bjm.v10i2.243Keywords:
focal segmentary glomerulosclerosis, proteinuria, treatment, remission, renal failureAbstract
Focal and segmental glomerulosclerosis is a rare clinicalpathological entity in pediatric age. It is currently considered one of the most frequent causes of kidney failure and is recognized worldwide as one of the three main causes of nephrotic syndrome. It is classified as primary or idiopathic, which frequently presents with nephrotic syndrome, and secondary, which is associated with non-nephrotic proteinuria and with a certain degree of renal failure. The diagnosis is suspected in children with corticosteroid-resistant nephrotic syndrome. Renal biopsy will provide confirmation. With immunosuppressive treatment, remissions are achieved in 20-25% of cases. Its prognosis is variable, and its evolution is marked by progression to end-stage renal failure in a period of 5-10 years, influenced by the level of proteinuria, renal and tubule-interstitial failure, and poor response to treatment.
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